【電機系書報討論演講訊息】

書報討論網頁：http://www.ee.nthu.edu.tw/~ee591000/

演講公告網址：/p/403-1175-2629-1.php

題   目：A CMOS Biomolecular Diagnose Platform

講   員：林致廷教授 (國立臺灣大學)

時         間：2014年4月18日(星期五) 下午2時20分 (2時10分入場)

地         點：台達館105教室

摘   要:

As developments of modern societies, an on-field and personalized diagnosis has become important for disease preventions and proper treatments.  To address this need, in this work, a polysilicon nanowire (poly-Si NW) based biosensor system-on-chip (bio-SSoC) is designed and fabricated by a 0.35μm 2-Poly-4-Metal (2P4M) complementary metal-oxide-semiconductor (CMOS) process provided by a commercialized semiconductor foundry.    Because of advantages of CMOS system-on-chip (SoC) technologies, the poly-Si NW biosensor is integrated with a chopper differential-difference amplifier (DDA) based analog-front-end (AFE), a successive approximation analog-to-digital converter (SAR ADC), and a microcontroller to have better sensing capabilities than a traditional Si NW discrete measuring system.  In addition, an on-off key (OOK) wireless transceiver is also integrated to form a wireless bio-SSoC technology.  This is a pioneer work to harness momentum of CMOS integrated technology into emerging bio-diagnosis technologies.  This integrated technology is experimentally examined to have a label-free and low-concentration biomolecular detection for both Hepatitis B Virus DNA (10 fM) and cardiac troponin I protein (3.2 pM).  Based on this work, the implemented wireless bio-SSoC has demonstrated a good biomolecular sensing characteristic and a potential for the low-cost and mobile applications.  As a consequence, this developed technology can be one of promising candidates for on-field and personalized applications in biomedical diagnosis.

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