【電機系書報討論演講訊息】

書報討論網址：http://www.ee.nthu.edu.tw/~ee591000/

演講公告網址：/p/403-1175-2629-1.php

題   目：The development of a neural prosthetic device with closed-loop epileptic seizure detection and conditional stimulations

講   員：闕河鳴 教授 (國立交通大學電機工程學系)

時          間：2012年09月21日(星期五) 下午2時20分

地          點：資電館B01演講廳
 

Abstract:

In recent years, alternative treatments and devices are proposed to investigate and treat epilepsy in addition to pharmacological and surgical treatments. Several prosthesis devices with deep brain stimulation (DBS) or vagus nerve stimulation are becoming popular treatments for epilepsy clients. These devices use open-loop continuous neural stimulations to control medical refractory epilepsies complementarily with a limited effective  rate of around 45%. Besides, by using continuous stimulations and an implantable battery, lifetime of such a device is often limited and periodically operations for clients are required to replace the battery/devices.

To overcome the above limitations, this work proposed a neural prosthetic device with closed-loop epileptic seizure detection and conditional therapeutic stimulation. The low-power analog front-end and bio-signal processing circuitries are used to detect the seizure's signal before it propagates to the whole cortex and activating stimulations to stop the seizure. The integrated circuitries and planner cortical electrodes are developed and verified. A prototype portable seizure controller is assembled using chip-on-board integration with real-time seizure detection algorithms.

The experimental results with four epileptic animal models using Long-Evans rats indicate that at least 92% of seizures are detected and seizure activities are suppressed by conditional stimulations. Long term animal tests using the portable device with integrated chips and electrodes are currently undergoing. The proposed prosthetic device with closed-loop epileptic seizure detection and stimulation yields a promising treatment for absence epilepsy.

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